| Gene Information | |
|---|---|
| Gene Name | BRD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 726 |
| Protein Names | Bromodomain-containing protein 3 (RING3-like protein) |
| Target Name | bromodomain-containing protein 3 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000169925 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15059 |
| Gene Card | BRD3 |
| Uniprot ID | Q15059 |
| Pfam | PF17035; PF00439 |
| In ASD | no |
| Allosteric Prediction | no (-0.557915703) |
| Ortholog in Animals | Alpaca_ BRD3 ( ortholog_one2one ) Dog_ BRD3 ( ortholog_one2one ) GuineaPig_ BRD3 ( ortholog_one2one ) Macaque_ BRD3 ( ortholog_one2one ) Mouse_ Brd3 ( ortholog_one2one ) Pig_ BRD3 ( ortholog_one2one ) Rat_ Brd3 ( ortholog_one2one ) Rabbit_ BRD3 ( ortholog_one2one ) |
| Ohnologs | BRDT |
| Paralogs | BRD2, BAZ1A, BRD4, BRDT, KAT2A, CECR2, BAZ2A, BAZ1B, BAZ2B, KAT2B, BPTF |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.010526(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2E7N (NMR - ) 2NXB (X-ray 1.40A ) 2OO1 (X-ray 1.70A ) 2YW5 (NMR - ) 3S91 (X-ray 2.06A ) 3S92 (X-ray 1.36A ) 5A7C (X-ray 1.90A ) 5HFR (X-ray 1.70A ) 5HJC (X-ray 2.60A ) 6BGG (NMR - ) 6BGH (NMR - ) 6I41 (X-ray 1.90A ) 6I5P (X-ray 1.81A ) 6I68 (X-ray 1.85A ) 6I7A (X-ray 2.20A ) 6QJU (X-ray 1.20A ) 6U4A (X-ray 1.88A ) 6ULP (X-ray 2.80A ) 7JMY (NMR - ) 7JQ8 (NMR - ) 7JYN (NMR - ) 7JYZ (NMR - ) 7L72 (X-ray 1.50A ) 7L9L (X-ray 1.55A ) 7LAY (X-ray 1.45A ) 7LAZ (X-ray 2.30A ) 7LB4 (X-ray 2.00A ) 7LBT (X-ray 2.70A ) 7RJK (X-ray 1.85A ) 7RJL (X-ray 1.50A ) 7RJM (X-ray 2.10A ) 7RJN (X-ray 1.95A ) |
| DBSNP | rs34609592 rs36093130 rs56017928 rs55754444 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q8K2F0}. Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q8K2F0}. |
| Mouse PG classification | NA |
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