| Gene Information | |
|---|---|
| Gene Name | CD33 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33) |
| Target Name | myeloid cell surface antigen cd33 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000105383 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20138 |
| Gene Card | CD33 |
| Uniprot ID | P20138 |
| Pfam | PF00047; PF07686 |
| In ASD | no |
| Allosteric Prediction | yes (0.215638625) |
| Ortholog in Animals | Alpaca_ CD33 ( ortholog_one2one ) Macaque_ CD33 ( ortholog_one2one ) Mouse_ Cd33 ( ortholog_one2many ) Rat_ Cd33 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | MAG, SIGLECL1, CD22, SIGLEC6, SIGLEC7, SIGLEC8, SIGLEC9, SIGLEC12, SIGLEC5, SIGLEC14, SIGLEC11, SIGLEC16, SIGLEC10, SIGLEC1, SIGLEC15, TMEM25 |
| Tissue | NA |
| Tissue Specificity | Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5IHB (X-ray 2.24A ) 5J06 (X-ray 2.66A ) 5J0B (X-ray 2.48A ) 6D48 (X-ray 1.78A ) 6D49 (X-ray 1.80A ) 6D4A (X-ray 1.75A ) 6TL8 (X-ray 2.80A ) 7AW6 (X-ray 1.95A ) |
| DBSNP | rs12459419 rs35814802 rs2455069 rs34919259 rs4082929 rs988337 rs11882250 rs58981829 rs2271652 rs35112940 rs35632246 |
| Subcellular location [CC] | [Isoform CD33M]: Cell membrane {ECO:0000269|PubMed:10611343, ECO:0000269|PubMed:28747436}; Single-pass type I membrane protein.; [Isoform CD33m]: Peroxisome {ECO:0000269|PubMed:28747436}. Note=CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes. {ECO:0000269|PubMed:28747436}. |
| Mouse PG classification | NA |
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