| Gene Information | |
|---|---|
| Gene Name | COL4A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1670 |
| Protein Names | Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000169031 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q01955 |
| Gene Card | COL4A3 |
| Uniprot ID | Q01955 |
| Pfam | PF01413; PF01391 |
| In ASD | no |
| Allosteric Prediction | no (-0.307354843) |
| Ortholog in Animals | Alpaca_ COL4A3 ( ortholog_one2one ) Dog_ COL4A3 ( ortholog_one2one ) Macaque_ COL4A3 ( ortholog_one2one ) Mouse_ Col4a3 ( ortholog_one2one ) Pig_ COL4A3 ( ortholog_one2one ) Rat_ Col4a3 ( ortholog_one2one ) Rabbit_ COL4A3 ( ortholog_one2one ) |
| Ohnologs | COL4A2, COL22A1, COL4A1, COL4A6 |
| Paralogs | COL9A2, COLQ, COL4A1, COL17A1, COL1A1, EDA, COL22A1, COL11A1, COL15A1, COL9A3, COL26A1, COL13A1, COL7A1, COL16A1, COL5A1, COL25A1, COL3A1, COL6A2, COL5A3, COL27A1, COL1A2, COL24A1, COL5A2, COL18A1, COL9A1, COL23A1, COL2A1, COL4A2, COL20A1, COL4A4, COL4A6, COL28A1, COL11A2, COL21A1, COL6A1, EMID1, COL4A5 |
| Tissue | NA |
| Tissue Specificity | Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3. Isoform 1 and isoform 3 are expressed at low levels in artery, fat, pericardium and peripherical nerve, but not in placenta, mesangium, skin, pleura and cultured umbilical endothelial cells. {ECO:0000269|PubMed:7523402, ECO:0000269|PubMed:8083201, ECO:0000269|PubMed:8505332}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5NB0 (X-ray 2.70A ) 6WKU (X-ray 1.76A ) |
| DBSNP | rs13424243 rs10178458 rs6436669 rs1422638161 rs55703767 rs1559878862 rs34505188 rs11677877 rs371405814 rs28381984 rs1315862965 rs200672668 rs375040636 rs56226424 rs763726708 rs121912827 rs121912826 rs267606745 rs1553764136 rs200443942 rs57611801 rs190598500 rs767033956 rs375290088 rs73996414 rs200302125 rs77964815 rs201697532 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |