| Gene Information | |
|---|---|
| Gene Name | COL2A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1487 |
| Protein Names | Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] |
| Target Name | collagen alpha-1(ii) chain |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000139219 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P02458 |
| Gene Card | COL2A1 |
| Uniprot ID | P02458 |
| Pfam | PF01410; PF01391; PF00093 |
| In ASD | no |
| Allosteric Prediction | no (-0.500278488) |
| Ortholog in Animals | Alpaca_ COL2A1 ( ortholog_one2one ) Dog_ COL2A1 ( ortholog_one2one ) GuineaPig_ COL2A1 ( ortholog_one2one ) Macaque_ COL2A1 ( ortholog_one2one ) Mouse_ Col2a1 ( ortholog_one2one ) Pig_ COL2A1 ( ortholog_one2one ) Rat_ Col2a1 ( ortholog_one2one ) Rabbit_ COL2A1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | COL9A2, COLQ, COL4A1, COL17A1, COL1A1, EDA, COL22A1, COL11A1, COL15A1, COL9A3, COL26A1, COL13A1, COL7A1, COL16A1, COL5A1, COL25A1, COL3A1, COL6A2, COL5A3, COL27A1, COL1A2, COL24A1, COL5A2, COL18A1, COL9A1, COL23A1, COL4A2, COL20A1, COL4A4, COL4A6, COL28A1, COL11A2, COL21A1, COL6A1, EMID1, COL4A5, COL4A3 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. {ECO:0000269|PubMed:2355003}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1U5M (NMR - ) 2FSE (X-ray 3.10A ) 2SEB (X-ray 2.50A ) 5NIR (X-ray 1.74A ) 5OCX (X-ray 1.75A ) 5OCY (X-ray 2.60A ) 6BIN (X-ray 2.50A ) 6HG7 (X-ray 1.00A ) 6NIX (X-ray 2.10A ) 7NZE (X-ray 2.05A ) |
| DBSNP | rs3803183 rs121912898 rs34392760 rs1050861 rs869312907 rs1592232040 rs121912872 rs121912876 rs121912877 rs121912894 rs121912871 rs794727339 rs794727339 rs121912881 rs121912880 rs1555167156 rs121912888 rs121912884 rs41263847 rs121912885 rs387906558 rs121912865 rs121912867 rs1193507525 rs121912879 rs121912882 rs121912875 rs121912878 rs121912874 rs121912895 rs753342774 rs41272041 rs121912868 rs1938737050 rs121912891 rs121912883 rs121912870 rs121912887 rs12721427 rs138498898 rs121912889 rs2070739 rs121912886 rs148838496 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}. |
| Mouse PG classification | HPG |
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