| Gene Information | |
|---|---|
| Gene Name | ITGA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1181 |
| Protein Names | Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) |
| Target Name | integrin alpha-2 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000164171 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P17301 |
| Gene Card | ITGA2 |
| Uniprot ID | P17301 |
| Pfam | PF01839; PF08441; PF00092 |
| In ASD | yes |
| Allosteric Prediction | yes (0.888366784) |
| Ortholog in Animals | Alpaca_ ITGA2 ( ortholog_one2one ) Dog_ ITGA2 ( ortholog_one2one ) GuineaPig_ ITGA2 ( ortholog_one2one ) Macaque_ ITGA2 ( ortholog_one2one ) Mouse_ Itga2 ( ortholog_one2one ) Pig_ ITGA2 ( ortholog_one2one ) Rat_ Itga2 ( ortholog_one2one ) Rabbit_ ITGA2 ( ortholog_one2one ) |
| Ohnologs | ITGA11, ITGA10 |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AOX (X-ray 2.10A ) 1DZI (X-ray 2.10A ) 1V7P (X-ray 1.90A ) 4BJ3 (X-ray 3.04A ) 5HJ2 (X-ray 2.15A ) 5THP (X-ray 3.01A ) 6ND8 (X-ray 2.90A ) 6ND9 (X-ray 2.90A ) 6NDA (X-ray 3.15A ) 6NDB (X-ray 3.20A ) 6NDC (X-ray 3.35A ) 6NDD (X-ray 3.05A ) 6NDE (X-ray 3.50A ) 6NDF (X-ray 3.05A ) 6NDG (X-ray 3.15A ) 6NDH (X-ray 2.90A ) |
| DBSNP | rs199808499 rs1801106 rs3212557 rs2287870 rs3212645 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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