| Gene Information | |
|---|---|
| Gene Name | COL18A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1754 |
| Protein Names | Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)] |
| Target Name | endostatin |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000182871 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P39060 |
| Gene Card | COL18A1 |
| Uniprot ID | P39060 |
| Pfam | PF01391; PF20010; PF06121; PF06482; PF01392 |
| In ASD | no |
| Allosteric Prediction | yes (0.318490322) |
| Ortholog in Animals | Alpaca_ COL18A1 ( ortholog_one2one ) Dog_ COL18A1 ( ortholog_one2one ) GuineaPig_ COL18A1 ( ortholog_one2one ) Macaque_ COL18A1 ( ortholog_one2one ) Mouse_ Col18a1 ( ortholog_one2one ) Pig_ COL18A1 ( ortholog_one2one ) Rat_ Col18a1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | COL9A2, COLQ, COL4A1, COL17A1, COL1A1, EDA, COL22A1, COL11A1, COL15A1, COL9A3, COL26A1, COL13A1, COL7A1, COL16A1, COL5A1, COL25A1, COL3A1, COL6A2, COL5A3, COL27A1, COL1A2, COL24A1, COL5A2, COL9A1, COL23A1, COL2A1, COL4A2, COL20A1, COL4A4, COL4A6, COL28A1, COL11A2, COL21A1, COL6A1, EMID1, COL4A5, COL4A3 |
| Tissue | NA |
| Tissue Specificity | Present in multiple organs with highest levels in liver, lung and kidney. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BNL (X-ray 2.90A ) 3HON (X-ray 3.00A ) 3HSH (X-ray 1.80A ) |
| DBSNP | rs61735029 rs114139997 rs749957649 rs11702494 rs8133886 rs62000962 rs79980197 rs2230693 rs12483377 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061}.; [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061}. Secreted {ECO:0000250|UniProtKB:P39061}.; [Endostatin]: Secreted {ECO:0000269|PubMed:10441114}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000305}. |
| Mouse PG classification | NA |
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