| Gene Information | |
|---|---|
| Gene Name | LARGE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 721 |
| Protein Names | Xylosyl- and glucuronyltransferase LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B) (LARGE xylosyl- and glucuronyltransferase 2) [Includes: Alpha-1,3-xylosyltransferase LARGE2 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE2 (EC 2.4.1.-)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000165905 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N3Y3 |
| Gene Card | LARGE2 |
| Uniprot ID | Q8N3Y3 |
| Pfam | PF01501 |
| In ASD | no |
| Allosteric Prediction | no (-1.558659419) |
| Ortholog in Animals | Alpaca_ LARGE2 ( ortholog_one2one ) Dog_ LARGE2 ( ortholog_one2one ) GuineaPig_ LARGE2 ( ortholog_one2one ) Macaque_ LARGE2 ( ortholog_one2one ) Mouse_ Large2 ( ortholog_one2one ) Pig_ LARGE2 ( ortholog_one2one ) Rat_ Large2 ( ortholog_one2one ) Rabbit_ LARGE2 ( ortholog_one2one ) |
| Ohnologs | LARGE1 |
| Paralogs | B4GAT1, GXYLT2, XXYLT1, GXYLT1, LARGE1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at high level in placenta, pancreas and kidney compared to LARGE. Not expressed in brain. {ECO:0000269|PubMed:15752776, ECO:0000269|PubMed:15958417}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17853729 rs11038713 rs2271851 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:15661757}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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