| Gene Information | |
|---|---|
| Gene Name | RGS6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 472 |
| Protein Names | Regulator of G-protein signaling 6 (RGS6) (S914) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000182732 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P49758 |
| Gene Card | RGS6 |
| Uniprot ID | P49758 |
| Pfam | PF00610; PF00631; PF00615; PF18148 |
| In ASD | no |
| Allosteric Prediction | yes (0.172662111) |
| Ortholog in Animals | Alpaca_ RGS6 ( ortholog_one2one ) Dog_ RGS6 ( ortholog_one2one ) GuineaPig_ RGS6 ( ortholog_one2one ) Macaque_ RGS6 ( ortholog_one2one ) Mouse_ Rgs6 ( ortholog_one2one ) Pig_ RGS6 ( ortholog_one2one ) Rat_ Rgs6 ( ortholog_one2one ) Rabbit_ RGS6 ( ortholog_one2one ) |
| Ohnologs | RGS7 |
| Paralogs | RGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS12, RGS21, AXIN1, RGS1, RGS11, RGS17, RGS7, RGS14, AXIN2, RGS22, RGS4, RGS9, RGS13, RGS19, RGS8, RGS16, RGS10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ES0 (X-ray 2.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12761221}. Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Membrane {ECO:0000269|PubMed:10521509}; Peripheral membrane protein {ECO:0000269|PubMed:10521509}. Nucleus {ECO:0000269|PubMed:12761221}. Cell membrane {ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with GNB5 mediates translocation to the nucleus. {ECO:0000269|PubMed:12761221}. |
| Mouse PG classification | NA |
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