| Gene Information | |
|---|---|
| Gene Name | COBL |
| Organism | Homo sapiens (Human) |
| Gene Length | 1261 |
| Protein Names | Protein cordon-bleu |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000106078 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O75128 |
| Gene Card | COBL |
| Uniprot ID | O75128 |
| Pfam | PF09469; PF02205 |
| In ASD | no |
| Allosteric Prediction | no (-0.880675649) |
| Ortholog in Animals | Alpaca_ COBL ( ortholog_one2one ) Dog_ COBL ( ortholog_one2one ) GuineaPig_ COBL ( ortholog_one2one ) Macaque_ COBL ( ortholog_one2one ) Mouse_ Cobl ( ortholog_one2one ) Rat_ Cobl ( ortholog_one2one ) Rabbit_ COBL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | COBLL1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4PL8 (X-ray 2.00A ) |
| DBSNP | rs17656599 rs10230120 rs2240090 rs2240089 rs17134128 rs17134127 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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