| Gene Information | |
|---|---|
| Gene Name | COASY |
| Organism | Homo sapiens (Human) |
| Gene Length | 564 |
| Protein Names | Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000068120 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13057 |
| Gene Card | COASY |
| Uniprot ID | Q13057 |
| Pfam | PF01121; PF01467 |
| In ASD | no |
| Allosteric Prediction | yes (0.219594432) |
| Ortholog in Animals | Alpaca_ COASY ( ortholog_one2one ) Dog_ COASY ( ortholog_one2one ) GuineaPig_ COASY ( ortholog_one2one ) Macaque_ COASY ( ortholog_one2one ) Mouse_ Coasy ( ortholog_one2one ) Pig_ COASY ( ortholog_one2one ) Rat_ Coasy ( ortholog_one2one ) Rabbit_ COASY ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DCAKD |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. {ECO:0000269|PubMed:11923312}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs615942 rs140709867 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:24360804}. Mitochondrion matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate. {ECO:0000269|PubMed:24360804}. |
| Mouse PG classification | NA |
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