| Gene Information | |
|---|---|
| Gene Name | SHROOM4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1493 |
| Protein Names | Protein Shroom4 (Second homolog of apical protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000158352 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9ULL8 |
| Gene Card | SHROOM4 |
| Uniprot ID | Q9ULL8 |
| Pfam | PF08687; PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-0.803801697) |
| Ortholog in Animals | Alpaca_ SHROOM4 ( ortholog_one2one ) Dog_ SHROOM4 ( ortholog_one2one ) GuineaPig_ SHROOM4 ( ortholog_one2one ) Macaque_ SHROOM4 ( ortholog_one2one ) Mouse_ Shroom4 ( ortholog_one2one ) Pig_ SHROOM4 ( ortholog_one2one ) Rat_ Shroom4 ( ortholog_one2one ) Rabbit_ SHROOM4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SHROOM2, SHROOM1, SHROOM3 |
| Tissue | NA |
| Tissue Specificity | Expressed in all fetal and adult tissues investigated. Expressed in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. In brain regions detected in cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe and putamen. The expression is strongest in the medulla and weakest in the cerebral cortex. {ECO:0000269|PubMed:16249884}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EDP (NMR - ) |
| DBSNP | rs189694750 rs150861758 rs3761506 rs3761505 rs2281571 rs121434620 rs28362302 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16249884, ECO:0000269|PubMed:16684770}. Note=Shows partial colocalization with the cytoplasmic pool of F-actin. |
| Mouse PG classification | NA |
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