| Gene Information | |
|---|---|
| Gene Name | NLRP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1062 |
| Protein Names | NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000022556 ) 3 ( ENSG00000273992 ) 3 ( ENSG00000274638 ) 3 ( ENSG00000275082 ) 3 ( ENSG00000275399 ) 3 ( ENSG00000275796 ) 3 ( ENSG00000275843 ) 3 ( ENSG00000277060 ) 3 ( ENSG00000278682 ) 3 ( ENSG00000278789 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NX02 |
| Gene Card | NLRP2 |
| Uniprot ID | Q9NX02 |
| Pfam | PF13516; PF05729; PF17776; PF17779; PF02758 |
| In ASD | no |
| Allosteric Prediction | no (-0.264799933) |
| Ortholog in Animals | Alpaca_ NLRP2 ( ortholog_one2one ) Mouse_ Nlrp2 ( ortholog_one2many ) Rat_ Nlrp2 ( ortholog_one2many ) |
| Ohnologs | RNH1 |
| Paralogs | PYDC2, NLRP9, NLRC5, NLRP14, NLRP7, NLRP4, CIITA, NOD1, NLRP8, NLRP10, NLRP3, NLRP5, NLRP6, NLRP11, NLRC3, NLRX1, NLRP12, NLRP13, NLRP1, NOD2 |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain (PubMed:15456791). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as brain, kidney, liver and spinal cord (PubMed:30877238). {ECO:0000269|PubMed:15456791, ECO:0000269|PubMed:30877238}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17699678 rs1194295774 rs3745904 rs4306647 rs61735082 rs61735083 rs34804158 rs1471763280 rs59779270 rs1043673 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:15456791}. |
| Mouse PG classification | NA |
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