| Gene Information | |
|---|---|
| Gene Name | CNTN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1026 |
| Protein Names | Contactin-4 (Brain-derived immunoglobulin superfamily protein 2) (BIG-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000144619 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IWV2 |
| Gene Card | CNTN4 |
| Uniprot ID | Q8IWV2 |
| Pfam | PF00041; PF07679 |
| In ASD | no |
| Allosteric Prediction | no (-0.768836249) |
| Ortholog in Animals | Alpaca_ CNTN4 ( ortholog_one2one ) Dog_ CNTN4 ( ortholog_one2one ) GuineaPig_ CNTN4 ( ortholog_one2one ) Macaque_ CNTN4 ( ortholog_one2one ) Mouse_ Cntn4 ( ortholog_one2one ) Pig_ CNTN4 ( ortholog_one2one ) Rat_ Cntn4 ( ortholog_one2one ) Rabbit_ CNTN4 ( ortholog_one2one ) |
| Ohnologs | CNTN1, SDK2, CNTN5, CNTN3, CNTN2 |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex. {ECO:0000269|PubMed:11013081, ECO:0000269|PubMed:14571131}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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