| Gene Information | |
|---|---|
| Gene Name | CNTN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1018 |
| Protein Names | Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000018236 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q12860 |
| Gene Card | CNTN1 |
| Uniprot ID | Q12860 |
| Pfam | PF00041; PF07679 |
| In ASD | no |
| Allosteric Prediction | yes (0.019454737) |
| Ortholog in Animals | Alpaca_ CNTN1 ( ortholog_one2one ) Dog_ CNTN1 ( ortholog_one2one ) GuineaPig_ CNTN1 ( ortholog_one2one ) Macaque_ CNTN1 ( ortholog_one2one ) Mouse_ Cntn1 ( ortholog_one2one ) Pig_ CNTN1 ( ortholog_one2one ) Rat_ Cntn1 ( ortholog_one2one ) Rabbit_ CNTN1 ( ortholog_one2one ) |
| Ohnologs | SDK2, CNTN3, CNTN6, CNTN4, SDK1, CNTN2 |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. {ECO:0000269|PubMed:2026173, ECO:0000269|PubMed:8164510}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EE2 (NMR - ) 3S97 (X-ray 2.30A ) |
| DBSNP | rs1056020 rs11553341 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. |
| Mouse PG classification | LPG |
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