| Gene Information | |
|---|---|
| Gene Name | CLDN18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 261 |
| Protein Names | Claudin-18 |
| Target Name | claudin-18 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000066405 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P56856 |
| Gene Card | CLDN18 |
| Uniprot ID | P56856 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-1.035386032) |
| Ortholog in Animals | Alpaca_ CLDN18 ( ortholog_one2one ) Dog_ CLDN18 ( ortholog_one2one ) GuineaPig_ CLDN18 ( ortholog_one2one ) Macaque_ CLDN18 ( ortholog_one2one ) Mouse_ Cldn18 ( ortholog_one2one ) Pig_ CLDN18 ( ortholog_one2one ) Rat_ Cldn18 ( ortholog_one2one ) Rabbit_ CLDN18 ( ortholog_one2one ) |
| Ohnologs | CLDN10, CLDN1, CLDN7, CLDN6, CLDN9, CLDN19 |
| Paralogs | CLDN1, CLDN5, CLDN8, CLDN3, CLDN20, CLDN11, CLDN14, CLDN7, CLDN10, CLDN9, CLDN17, CLDN24, CLDN22, CLDN23, CLDN4, CLDN15, CLDN19, CLDN34, CLDN2, CLDN25, CLDN16, CLDN6 |
| Tissue | stomach, lung |
| Tissue Specificity | Isoform A1: Expression is restricted to the lung (PubMed:19047087). Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087). {ECO:0000269|PubMed:19047087}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17204075 |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in epithelial cells. {ECO:0000250|UniProtKB:P56857}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |