| Gene Information | |
|---|---|
| Gene Name | CNR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5) |
| Target Name | cannabinoid receptor 2 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000188822 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P34972 |
| Gene Card | CNR2 |
| Uniprot ID | P34972 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.037820531) |
| Ortholog in Animals | Alpaca_ CNR2 ( ortholog_one2one ) Dog_ CNR2 ( ortholog_one2one ) GuineaPig_ CNR2 ( ortholog_one2one ) Macaque_ CNR2 ( ortholog_one2one ) Mouse_ Cnr2 ( ortholog_one2one ) Pig_ CNR2 ( ortholog_one2one ) Rat_ Cnr2 ( ortholog_one2one ) Rabbit_ CNR2 ( ortholog_one2one ) |
| Ohnologs | CNR1 |
| Paralogs | S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR1, LPAR2, LPAR3, MC5R, MC1R, MC2R, MC3R, MC4R, CNR1, GPR3, GPR119, GPR6, GPR12 |
| Tissue | spleen |
| Tissue Specificity | Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. {ECO:0000269|PubMed:12153574, ECO:0000269|PubMed:12511587, ECO:0000269|PubMed:14657172, ECO:0000269|PubMed:15266552, ECO:0000269|PubMed:18692962, ECO:0000269|PubMed:19496827, ECO:0000269|PubMed:7556170}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KI9 (NMR - ) 5ZTY (X-ray 2.80A ) 6KPC (X-ray 3.20A ) 6KPF (EM 2.90A ) 6PT0 (EM 3.20A ) |
| DBSNP | rs2501432 rs2229579 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}. |
| Mouse PG classification | NA |
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