| Gene Information | |
|---|---|
| Gene Name | CNR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 472 |
| Protein Names | Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) |
| Target Name | cannabinoid receptor 1 |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000118432 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21554 |
| Gene Card | CNR1 |
| Uniprot ID | P21554 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.750602762) |
| Ortholog in Animals | Alpaca_ CNR1 ( ortholog_one2one ) GuineaPig_ CNR1 ( ortholog_one2one ) Macaque_ CNR1 ( ortholog_one2one ) Mouse_ Cnr1 ( ortholog_one2one ) Pig_ CNR1 ( ortholog_one2one ) Rat_ Cnr1 ( ortholog_one2one ) |
| Ohnologs | CNR2 |
| Paralogs | S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR1, LPAR2, LPAR3, MC5R, MC1R, MC2R, MC3R, MC4R, CNR2, GPR3, GPR119, GPR6, GPR12 |
| Tissue | cerebral.cortex |
| Tissue Specificity | Widely expressed, with highest levels in fetal and adult brain. Expression levels of isoform 2 and isoform 3 are much lower than those of isoform 1. {ECO:0000269|PubMed:15620723}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1LVQ (NMR - ) 1LVR (NMR - ) 2B0Y (NMR - ) 2KOE (NMR - ) 2MZ2 (NMR - ) 2MZ3 (NMR - ) 2MZA (NMR - ) 5TGZ (X-ray 2.80A ) 5U09 (X-ray 2.60A ) 5XR8 (X-ray 2.95A ) 5XRA (X-ray 2.80A ) 6KPG (EM 3.00A ) 6KQI (X-ray 3.25A ) 6N4B (EM 3.00A ) 7FEE (X-ray 2.70A ) 7V3Z (X-ray 3.29A ) 7WV9 (EM 3.36A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21895628}; Multi-pass membrane protein {ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727}. Membrane raft {ECO:0000269|PubMed:21895628}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P47746}. Cell projection, axon {ECO:0000250|UniProtKB:P20272}. Presynapse {ECO:0000250|UniProtKB:P20272}. Note=Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity). {ECO:0000250|UniProtKB:P20272, ECO:0000250|UniProtKB:P47746}. |
| Mouse PG classification | NA |
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