| Gene Information | |
|---|---|
| Gene Name | GLP1R |
| Organism | Homo sapiens (Human) |
| Gene Length | 463 |
| Protein Names | Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) |
| Target Name | glucagon-like peptide 1 receptor |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000112164 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P43220 |
| Gene Card | GLP1R |
| Uniprot ID | P43220 |
| Pfam | PF00002; PF02793 |
| In ASD | yes |
| Allosteric Prediction | yes (1.816627066) |
| Ortholog in Animals | Alpaca_ GLP1R ( ortholog_one2one ) Dog_ GLP1R ( ortholog_one2one ) GuineaPig_ GLP1R ( ortholog_one2one ) Macaque_ GLP1R ( ortholog_one2one ) Mouse_ Glp1r ( ortholog_one2one ) Pig_ GLP1R ( ortholog_one2one ) Rat_ Glp1r ( ortholog_one2one ) Rabbit_ GLP1R ( ortholog_one2one ) |
| Ohnologs | CALCR, GIPR, CALCRL, VIPR1 |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3C59 (X-ray 2.30A ) 3C5T (X-ray 2.10A ) 3IOL (X-ray 2.10A ) 4ZGM (X-ray 1.80A ) 5E94 (X-ray 2.00A ) 5NX2 (X-ray 3.70A ) 5OTT (X-ray 1.92A ) 5OTU (X-ray 1.80A ) 5OTV (X-ray 2.00A ) 5OTW (X-ray 2.10A ) 5OTX (X-ray 2.00A ) 5VEW (X-ray 2.70A ) 5VEX (X-ray 3.00A ) 6B3J (EM 3.30A ) 6GB1 (X-ray 2.73A ) 6ORV (EM 3.00A ) 6VCB (EM 3.30A ) 6X18 (EM 2.10A ) 6X19 (EM 2.10A ) 6X1A (EM 2.50A ) 6XOX (EM 3.10A ) 7C2E (EM 4.20A ) 7DUQ (EM 2.50A ) 7DUR (EM 3.30A ) 7E14 (EM 2.90A ) 7EVM (EM 2.50A ) 7FIM (EM 3.40A ) 7KI0 (EM 2.50A ) 7KI1 (EM 2.50A ) 7LCI (EM 2.90A ) 7LCJ (EM 2.82A ) 7LCK (EM 3.24A ) 7LLL (EM 3.70A ) 7LLY (EM 3.30A ) 7RG9 (EM 3.20A ) 7RGP (EM 2.90A ) 7RTB (EM 2.14A ) 7S15 (EM 3.80A ) 7S1M (EM 2.41A ) 7S3I (EM 2.51A ) 7VBH (EM 3.00A ) 7VBI (EM 3.00A ) 7X8R (EM 2.61A ) 7X8S (EM 3.09A ) |
| DBSNP | rs10305420 rs10305421 rs2295006 rs3765467 rs6923761 rs1042044 rs10305492 rs10305493 rs10305510 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}; Multi-pass membrane protein {ECO:0000269|PubMed:28514449}. |
| Mouse PG classification | NA |
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