| Gene Information | |
|---|---|
| Gene Name | CNIH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 144 |
| Protein Names | Protein cornichon homolog 1 (CNIH-1) (Cornichon family AMPA receptor auxiliary protein 1) (Protein cornichon homolog) (T-cell growth-associated molecule 77) (TGAM77) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000100528 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95406 |
| Gene Card | CNIH1 |
| Uniprot ID | O95406 |
| Pfam | PF03311 |
| In ASD | no |
| Allosteric Prediction | no (-0.788273513) |
| Ortholog in Animals | Alpaca_ CNIH1 ( ortholog_one2one ) Dog_ GMFB ( ortholog_one2one ) Macaque_ CNIH1 ( ortholog_one2one ) Mouse_ Cnih1 ( ortholog_one2one ) Pig_ CNIH1 ( ortholog_one2one ) Rat_ Cnih1 ( ortholog_one2one ) Rabbit_ CNIH1 ( ortholog_one2one ) |
| Ohnologs | CNIH3, CNIH2 |
| Paralogs | CNIH3, CNIH2, CNIH4, PPCS |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:17607000}; Multi-pass membrane protein {ECO:0000269|PubMed:17607000}. Golgi apparatus membrane {ECO:0000269|PubMed:17607000}. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus. |
| Mouse PG classification | NA |
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