| Gene Information | |
|---|---|
| Gene Name | CNFN |
| Organism | Homo sapiens (Human) |
| Gene Length | 112 |
| Protein Names | Cornifelin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000105427 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BYD5 |
| Gene Card | CNFN |
| Uniprot ID | Q9BYD5 |
| Pfam | PF04749 |
| In ASD | no |
| Allosteric Prediction | no (-1.496195375) |
| Ortholog in Animals | Alpaca_ CNFN ( ortholog_one2one ) Dog_ CNFN ( ortholog_one2one ) GuineaPig_ CNFN ( ortholog_one2one ) Macaque_ CNFN ( ortholog_one2one ) Mouse_ Cnfn ( ortholog_one2one ) Pig_ CNFN ( ortholog_one2one ) Rat_ Cnfn ( ortholog_one2one ) Rabbit_ CNFN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PLAC8, PLAC8L1 |
| Tissue | esophagus, tongue, esophagus.mucosa |
| Tissue Specificity | Abundant in the cervix. Moderately abundant in the uterus and fetal skin. Expression is markedly increased in psoriatic skin (18.5 fold increase in comparison with normal skin) and its overexpression alters the protein composition of cornified cell envelope (CE), but does not affect keratinocyte differentiation. Expressed in the granular cell layer of epidermis in uninvolved psoriatic skin and in the psoriatic lesions it is found in the upper-spinous layer. Increased expression also seen in atopic dermatitis (14.3 fold increase in comparison with normal skin) and mycosis fungoides (4.6 fold increase in comparison with normal skin) and in both conditions expressed in the granular cell layer of epidermis. {ECO:0000269|PubMed:15147942}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |