| Gene Information | |
|---|---|
| Gene Name | MRS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 426 |
| Protein Names | Pannexin-1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96RD7 |
| Gene Card | PANX1 |
| Uniprot ID | Q96RD7 |
| Pfam | PF00876 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116). {ECO:0000269|PubMed:30918116}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6LTN (EM 3.10A ) 6LTO (EM 3.10A ) 6M02 (EM 3.20A ) 6M66 (EM 4.10A ) 6M67 (EM 3.60A ) 6M68 (EM 4.60A ) 6V6D (EM 3.77A ) 6WBF (EM 2.83A ) 6WBG (EM 2.97A ) 6WBI (EM 4.39A ) 6WBK (EM 6.01A ) 6WBL (EM 5.13A ) 6WBM (EM 2.86A ) 6WBN (EM 2.83A ) 7DWB (EM 3.15A ) 7F8J (EM 3.60A ) 7F8N (EM 3.40A ) 7F8O (EM 3.60A ) 7WSV (EM 4.50A ) |
| DBSNP | rs1138800 rs143240087 rs12793348 rs1591529130 rs1212949833 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:30918116}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction {ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:17715132}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. |
| Mouse PG classification | NA |
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