| Gene Information | |
|---|---|
| Gene Name | PHB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 299 |
| Protein Names | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) |
| Target Name | prohibitin-2 |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000215021 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q99623 |
| Gene Card | PHB2 |
| Uniprot ID | Q99623 |
| Pfam | PF01145 |
| In ASD | no |
| Allosteric Prediction | yes (0.271840652) |
| Ortholog in Animals | Alpaca_ PHB2 ( ortholog_one2one ) Dog_ PHB2 ( ortholog_one2one ) GuineaPig_ PHB2 ( ortholog_one2one ) Macaque_ PHB2 ( ortholog_one2one ) Mouse_ Phb2 ( ortholog_one2one ) Pig_ PHB2 ( ortholog_one2one ) Rat_ Phb2 ( ortholog_one2one ) Rabbit_ PHB2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PHB1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6IQE (X-ray 1.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329}. Cytoplasm {ECO:0000269|PubMed:19496786, ECO:0000269|PubMed:32276428}. Nucleus {ECO:0000269|PubMed:19496786, ECO:0000269|PubMed:20959514}. Cell membrane {ECO:0000269|PubMed:22997079, ECO:0000269|PubMed:24003225}.; [Isoform 1]: Mitochondrion inner membrane {ECO:0000305|PubMed:31522117}.; [Isoform 2]: Mitochondrion inner membrane {ECO:0000305|PubMed:31522117}. |
| Mouse PG classification | NA |
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