| Gene Information | |
|---|---|
| Gene Name | CNA |
| Organism | Homo sapiens (Human) |
| Gene Length | 521 |
| Protein Names | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q08209 |
| Gene Card | PPP3CA |
| Uniprot ID | Q08209 |
| Pfam | PF00149 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in keratinocytes (at protein level) (PubMed:29043977). Expressed in lymphoblasts (at protein level) (PubMed:30254215). {ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:30254215}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.209548(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AUI (X-ray 2.10A ) 1M63 (X-ray 2.80A ) 1MF8 (X-ray 3.10A ) 2JOG (NMR - ) 2JZI (NMR - ) 2P6B (X-ray 2.30A ) 2R28 (X-ray 1.86A ) 2W73 (X-ray 1.45A ) 3LL8 (X-ray 2.00A ) 4F0Z (X-ray 1.70A ) 4Q5U (X-ray 1.95A ) 5C1V (X-ray 3.35A ) 5SVE (X-ray 2.60A ) 6NUC (X-ray 1.90A ) 6NUF (X-ray 1.90A ) 6NUU (X-ray 2.30A ) 6UUQ (X-ray 1.85A ) |
| DBSNP | rs1553925558 rs199706529 rs1553923787 rs1553920374 rs1560567347 rs1560567337 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722}. Cell membrane {ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:28881575}; Peripheral membrane protein {ECO:0000269|PubMed:22343722}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P63329}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P63329}. Cell projection, dendritic spine {ECO:0000269|PubMed:22343722}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). {ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:22343722}. |
| Mouse PG classification | NA |
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