| Gene Information | |
|---|---|
| Gene Name | PARP10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1025 |
| Protein Names | Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000178685 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q53GL7 |
| Gene Card | PARP10 |
| Uniprot ID | Q53GL7 |
| Pfam | PF00644 |
| In ASD | no |
| Allosteric Prediction | yes (0.087600814) |
| Ortholog in Animals | Alpaca_ PARP10 ( ortholog_one2one ) GuineaPig_ PARP10 ( ortholog_one2one ) Mouse_ Parp10 ( ortholog_one2one ) Rat_ Parp10 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZC3HAV1L, PARP14, PARP12, PARP9, PARP11, PARP15, ZC3HAV1, TIPARP |
| Tissue | NA |
| Tissue Specificity | Highly expressed in spleen and thymus (PubMed:15674325). Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes (PubMed:15674325). Low expression in heart, brain, placenta, lung, skeletal muscle, and colon (PubMed:15674325). {ECO:0000269|PubMed:15674325}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2DHX (NMR - ) 3HKV (X-ray 2.10A ) 5LX6 (X-ray 1.25A ) 6FXI (X-ray 2.60A ) |
| DBSNP | rs11136344 rs11136343 rs11544989 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:15674325}. Cytoplasm {ECO:0000269|PubMed:15674325}. Note=Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325). A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325). {ECO:0000269|PubMed:15674325}. |
| Mouse PG classification | NA |
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