| Gene Information | |
|---|---|
| Gene Name | B4GAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 415 |
| Protein Names | Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000174684 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O43505 |
| Gene Card | B4GAT1 |
| Uniprot ID | O43505 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.793995584) |
| Ortholog in Animals | Alpaca_ B4GAT1 ( ortholog_one2one ) Dog_ B4GAT1 ( ortholog_one2one ) GuineaPig_ B4GAT1 ( ortholog_one2one ) Macaque_ B4GAT1 ( ortholog_one2one ) Mouse_ B4gat1 ( ortholog_one2one ) Pig_ B4GAT1 ( ortholog_one2one ) Rat_ B4gat1 ( ortholog_one2one ) Rabbit_ B4GAT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GXYLT2, XXYLT1, LARGE2, GXYLT1, LARGE1 |
| Tissue | NA |
| Tissue Specificity | In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver. {ECO:0000269|PubMed:9405606}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.074074(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35429253 rs397509397 rs397509396 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:19587235, ECO:0000269|PubMed:23359570, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:23359570}. Note=Localizes near the trans-Golgi apparatus. {ECO:0000269|PubMed:25279699}. |
| Mouse PG classification | NA |
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