| Gene Information | |
|---|---|
| Gene Name | FOCAD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1801 |
| Protein Names | Focadhesin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000188352 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5VW36 |
| Gene Card | FOCAD |
| Uniprot ID | Q5VW36 |
| Pfam | PF12530; PF11229 |
| In ASD | no |
| Allosteric Prediction | no (-0.827841415) |
| Ortholog in Animals | Alpaca_ FOCAD ( ortholog_one2one ) Dog_ FOCAD ( ortholog_one2one ) GuineaPig_ FOCAD ( ortholog_one2one ) Macaque_ FOCAD ( ortholog_one2one ) Mouse_ Focad ( ortholog_one2one ) Pig_ FOCAD ( ortholog_one2one ) Rat_ Focad ( ortholog_one2one ) Rabbit_ FOCAD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines. {ECO:0000269|PubMed:16877819, ECO:0000269|PubMed:22427331}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10511687 rs10441706 rs17832431 rs7875872 rs10964742 rs3206852 rs3206852 rs3206852 rs4977881 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion. Note=Colocalizes with VCL in astrocytes. |
| Mouse PG classification | NA |
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