| Gene Information | |
|---|---|
| Gene Name | CLTC |
| Organism | Homo sapiens (Human) |
| Gene Length | 1675 |
| Protein Names | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000141367 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q00610 |
| Gene Card | CLTC |
| Uniprot ID | Q00610 |
| Pfam | PF00637; PF09268; PF01394 |
| In ASD | no |
| Allosteric Prediction | yes (0.86021137) |
| Ortholog in Animals | Alpaca_ CLTC ( ortholog_one2one ) Dog_ CLTC ( ortholog_one2one ) GuineaPig_ CLTC ( ortholog_one2one ) Macaque_ CLTC ( ortholog_one2one ) Mouse_ Cltc ( ortholog_one2one ) Pig_ CLTC ( ortholog_one2one ) Rat_ Cltc ( ortholog_one2one ) Rabbit_ CLTC ( ortholog_one2one ) |
| Ohnologs | CLTCL1 |
| Paralogs | CLTCL1, CLHC1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XZG (X-ray 1.70A ) 4G55 (X-ray 1.69A ) 6E4L (X-ray 1.60A ) 6QNN (X-ray 2.03A ) 6QNP (X-ray 2.70A ) 7BN1 (X-ray 1.97A ) 7BN2 (X-ray 1.97A ) |
| DBSNP | rs1555606635 rs1555607159 |
| Subcellular location [CC] | Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:23918938}. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269|PubMed:25596274}. |
| Mouse PG classification | NA |
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