| Gene Information | |
|---|---|
| Gene Name | PRMT8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 394 |
| Protein Names | Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000111218 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NR22 |
| Gene Card | PRMT8 |
| Uniprot ID | Q9NR22 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.879798519) |
| Ortholog in Animals | Alpaca_ PRMT8 ( ortholog_one2one ) Dog_ PRMT8 ( ortholog_one2one ) GuineaPig_ PRMT8 ( ortholog_one2one ) Macaque_ PRMT8 ( ortholog_one2one ) Mouse_ Prmt8 ( ortholog_one2one ) Pig_ PRMT8 ( ortholog_one2one ) Rat_ Prmt8 ( ortholog_one2one ) Rabbit_ PRMT8 ( ortholog_one2one ) |
| Ohnologs | PRMT1 |
| Paralogs | PRMT2, PRMT7, PRMT9, PRMT1, CARM1, PRMT6, PRMT3 |
| Tissue | brain |
| Tissue Specificity | Brain-specific. {ECO:0000269|PubMed:16051612}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4X41 (X-ray 3.50A ) 5DST (X-ray 2.96A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:26876602}; Lipid-anchor {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:26876602}; Cytoplasmic side {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585, ECO:0000269|PubMed:26876602}. |
| Mouse PG classification | NA |
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