| Gene Information | |
|---|---|
| Gene Name | NAALADL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | Aminopeptidase NAALADL1 (EC 3.4.11.-) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase) (N-acetylated-alpha-linked acidic dipeptidase-like protein) (NAALADase L) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000168060 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UQQ1 |
| Gene Card | NAALADL1 |
| Uniprot ID | Q9UQQ1 |
| Pfam | PF02225; PF04389; PF04253 |
| In ASD | no |
| Allosteric Prediction | no (-0.120861037) |
| Ortholog in Animals | Alpaca_ NAALADL1 ( ortholog_one2one ) Dog_ NAALADL1 ( ortholog_one2one ) GuineaPig_ NAALADL1 ( ortholog_one2one ) Macaque_ NAALADL1 ( ortholog_one2one ) Mouse_ Naaladl1 ( ortholog_one2one ) Pig_ NAALADL1 ( ortholog_one2one ) Rat_ Naaladl1 ( ortholog_one2one ) |
| Ohnologs | NAALAD2, FOLH1B |
| Paralogs | NAALAD2, FOLH1, NAALADL2, TFR2, TFRC |
| Tissue | small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Detected in small intestine (at protein level) (PubMed:25752612). Detected in ileum (PubMed:9388249). Detected in small intestine, spleen and testis. Isoform 2 and isoform 3 are found in the small intestine and colon (PubMed:10085079). {ECO:0000269|PubMed:10085079, ECO:0000269|PubMed:25752612, ECO:0000269|PubMed:9388249}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4TWE (X-ray 1.75A ) |
| DBSNP | rs35422506 rs12223986 rs36053340 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000250|UniProtKB:O54697}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54697}. Note=Ileal brush border membrane. {ECO:0000250|UniProtKB:O54697}. |
| Mouse PG classification | NA |
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