| Gene Information | |
|---|---|
| Gene Name | FAD158 |
| Organism | Homo sapiens (Human) |
| Gene Length | 803 |
| Protein Names | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TDW0 |
| Gene Card | LRRC8C |
| Uniprot ID | Q8TDW0 |
| Pfam | PF13306; PF13855; PF12534 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:15564382}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs474536 rs12032393 rs12036569 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000269|PubMed:24790029}. |
| Mouse PG classification | NA |
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