| Gene Information | |
|---|---|
| Gene Name | FZD7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 574 |
| Protein Names | Frizzled-7 (Fz-7) (hFz7) (FzE3) |
| Target Name | frizzled-7 receptor |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000155760 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75084 |
| Gene Card | FZD7 |
| Uniprot ID | O75084 |
| Pfam | PF01534; PF01392 |
| In ASD | no |
| Allosteric Prediction | no (-0.924297598) |
| Ortholog in Animals | Alpaca_ FZD7 ( ortholog_one2one ) Dog_ FZD7 ( ortholog_one2one ) GuineaPig_ FZD7 ( ortholog_one2one ) Macaque_ FZD7 ( ortholog_one2one ) Mouse_ Fzd7 ( ortholog_one2one ) Pig_ FZD7 ( ortholog_one2one ) Rat_ Fzd7 ( ortholog_one2one ) Rabbit_ FZD7 ( ortholog_one2one ) |
| Ohnologs | FZD3, FZD1, FZD2 |
| Paralogs | SFRP5, SFRP1, FZD5, FZD2, FZD10, FZD9, SFRP4, FRZB, FZD6, FZD8, SMO, FZD1, SFRP2, FZD4, FZD3 |
| Tissue | NA |
| Tissue Specificity | High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Z33 (X-ray 2.45A ) 5T44 (X-ray 1.99A ) 5URV (X-ray 2.20A ) 5WBS (X-ray 2.88A ) 6NE2 (X-ray 1.30A ) 6NE4 (X-ray 1.65A ) 6O3A (X-ray 2.10A ) 6O3B (X-ray 2.50A ) 7EVW (EM 3.22A ) |
| DBSNP | rs35111363 rs755615030 rs34908164 rs35600847 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:27386966}; Multi-pass membrane protein {ECO:0000269|PubMed:27386966}. Endosome membrane {ECO:0000269|PubMed:27386966}; Multi-pass membrane protein {ECO:0000269|PubMed:27386966}. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. {ECO:0000269|PubMed:27386966}. |
| Mouse PG classification | NA |
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