| Gene Information | |
|---|---|
| Gene Name | CLP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 742 |
| Protein Names | Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000172409 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5KU26 |
| Gene Card | COLEC12 |
| Uniprot ID | Q5KU26 |
| Pfam | PF01391; PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.790004009) |
| Ortholog in Animals | Alpaca_ CLP1 ( ortholog_one2one ) Dog_ CLP1 ( ortholog_one2one ) GuineaPig_ CLP1 ( ortholog_one2one ) Macaque_ CLP1 ( ortholog_one2one ) Mouse_ Clp1 ( ortholog_one2one ) Pig_ CLP1 ( ortholog_one2one ) Rat_ Clp1 ( ortholog_one2one ) Rabbit_ CLP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NOL9 |
| Tissue | NA |
| Tissue Specificity | Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2OX8 (X-ray 2.50A ) |
| DBSNP | rs17855029 rs8098850 rs2305025 rs2305027 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface. |
| Mouse PG classification | NA |
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