| Gene Information | |
|---|---|
| Gene Name | HAS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 553 |
| Protein Names | Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid synthase 3) (HA synthase 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000103044 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O00219 |
| Gene Card | HAS3 |
| Uniprot ID | O00219 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.327430593) |
| Ortholog in Animals | Alpaca_ HAS3 ( ortholog_one2one ) Dog_ HAS3 ( ortholog_one2one ) GuineaPig_ HAS3 ( ortholog_one2one ) Macaque_ HAS3 ( ortholog_one2one ) Mouse_ Has3 ( ortholog_one2one ) Pig_ HAS3 ( ortholog_one2one ) Rat_ Has3 ( ortholog_one2one ) Rabbit_ HAS3 ( ortholog_one2one ) |
| Ohnologs | HAS2 |
| Paralogs | HAS2, HAS1 |
| Tissue | lung, urinary.bladder |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2232229 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:26883802, ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:25795779}; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O08650}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:26883802}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane (PubMed:26883802). Actives only when present in plasma membrane (By similarity). O-GlcNAcylation controls its membrane localization (PubMed:26883802). A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP-GlcNAc (PubMed:26883802). {ECO:0000250|UniProtKB:O08650, ECO:0000269|PubMed:26883802}. |
| Mouse PG classification | NA |
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