| Gene Information | |
|---|---|
| Gene Name | CLK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 499 |
| Protein Names | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) |
| Target Name | cdc-like kinase 2 |
| Target Type | Patented-recorded target |
| Gene Age | >4290 ( ENSG00000176444 ) 3 ( ENSG00000261893 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49760 |
| Gene Card | CLK2 |
| Uniprot ID | P49760 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.201036426) |
| Ortholog in Animals | Alpaca_ CLK2 ( ortholog_one2one ) Dog_ CLK2 ( ortholog_one2one ) GuineaPig_ CLK2 ( ortholog_one2one ) Mouse_ Clk2 ( ortholog_one2one ) Pig_ CLK2 ( ortholog_one2one ) Rat_ Clk2 ( ortholog_one2one ) Rabbit_ CLK2 ( ortholog_one2one ) |
| Ohnologs | CLK3 |
| Paralogs | CLK1, HIPK3, DYRK4, DYRK1B, HIPK1, CLK3, HIPK4, DYRK3, HIPK2, CLK4, DYRK2, DYRK1A |
| Tissue | NA |
| Tissue Specificity | Endothelial cells (PubMed:19168442). Expressed in androgen-dependent prostate cancer cells (PubMed:28289210). {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.005405(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3NR9 (X-ray 2.89A ) 5UNP (X-ray 2.92A ) 6FYI (X-ray 2.60A ) 6FYK (X-ray 2.39A ) 6FYL (X-ray 1.95A ) 6KHE (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28289210}.; [Isoform 1]: Nucleus {ECO:0000269|PubMed:9637771}. Nucleus speckle {ECO:0000269|PubMed:9637771}. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250|UniProtKB:O35491}.; [Isoform 2]: Nucleus speckle {ECO:0000269|PubMed:9637771}. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. {ECO:0000269|PubMed:9637771}. |
| Mouse PG classification | NA |
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