Gene Information | |
---|---|
Gene Name | CLK1 |
Organism | Homo sapiens (Human) |
Gene Length | 484 |
Protein Names | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) |
Target Name | dual specificity protein kinase clk1 |
Target Type | NA |
Gene Age | 680 ( ENSG00000013441 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | P49759 |
Gene Card | CLK1 |
Uniprot ID | P49759 |
Pfam | PF00069 |
In ASD | no |
Allosteric Prediction | yes (0.610678528) |
Ortholog in Animals | Alpaca_ CLK1 ( ortholog_one2one ) Dog_ CLK1 ( ortholog_one2one ) GuineaPig_ CLK1 ( ortholog_one2one ) Macaque_ CLK1 ( ortholog_one2one ) Mouse_ Clk1 ( ortholog_one2one ) Pig_ CLK1 ( ortholog_one2one ) Rat_ Clk1 ( ortholog_one2one ) Rabbit_ CLK1 ( ortholog_one2one ) |
Ohnologs | CLK4 |
Paralogs | HIPK3, DYRK4, DYRK1B, HIPK1, CLK3, HIPK4, DYRK3, HIPK2, CLK4, DYRK2, DYRK1A, CLK2 |
Tissue | NA |
Tissue Specificity | Endothelial cells. {ECO:0000269|PubMed:19168442}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 1Z57 (X-ray 1.70A ) 2VAG (X-ray 1.80A ) 5J1V (X-ray 2.52A ) 5J1W (X-ray 2.42A ) 5X8I (X-ray 1.90A ) 6FT8 (X-ray 1.45A ) 6FT9 (X-ray 1.87A ) 6FYO (X-ray 2.32A ) 6G33 (X-ray 2.05A ) 6I5H (X-ray 1.49A ) 6I5I (X-ray 1.60A ) 6I5K (X-ray 2.30A ) 6I5L (X-ray 2.55A ) 6KHD (X-ray 2.70A ) 6Q8K (X-ray 2.29A ) 6Q8P (X-ray 3.00A ) 6QTY (X-ray 1.65A ) 6R3D (X-ray 1.85A ) 6R6E (X-ray 2.25A ) 6R6X (X-ray 2.05A ) 6R8J (X-ray 1.75A ) 6RAA (X-ray 2.10A ) 6TW2 (X-ray 1.80A ) 6YTA (X-ray 2.30A ) 6YTD (X-ray 2.00A ) 6YTE (X-ray 2.30A ) 6YTG (X-ray 1.95A ) 6YTI (X-ray 2.40A ) 6Z4Z (X-ray 2.07A ) 6Z50 (X-ray 1.60A ) 6ZLN (X-ray 1.70A ) 7AK3 (X-ray 2.50A ) 7O9Y (X-ray 1.66A ) 7OA0 (X-ray 1.81A ) 7OPG (X-ray 1.93A ) |
DBSNP | rs55989135 rs6735666 rs56135616 rs35412475 rs35393352 rs12709 |
Subcellular location [CC] | Nucleus. |
Mouse PG classification | NA |
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