Gene Information
Gene NameCLK1
OrganismHomo sapiens (Human)
Gene Length484
Protein NamesDual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Target Namedual specificity protein kinase clk1
Target TypeNA
Gene Age680 ( ENSG00000013441 )
Evolutionary StageEukaryota
AlphaFoldDBP49759
Gene CardCLK1
Uniprot IDP49759
PfamPF00069
In ASDno
Allosteric Predictionyes (0.610678528)
Ortholog in AnimalsAlpaca_ CLK1 ( ortholog_one2one )
Dog_ CLK1 ( ortholog_one2one )
GuineaPig_ CLK1 ( ortholog_one2one )
Macaque_ CLK1 ( ortholog_one2one )
Mouse_ Clk1 ( ortholog_one2one )
Pig_ CLK1 ( ortholog_one2one )
Rat_ Clk1 ( ortholog_one2one )
Rabbit_ CLK1 ( ortholog_one2one )
OhnologsCLK4
ParalogsHIPK3, DYRK4, DYRK1B, HIPK1, CLK3, HIPK4, DYRK3, HIPK2, CLK4, DYRK2, DYRK1A, CLK2
TissueNA
Tissue SpecificityEndothelial cells. {ECO:0000269|PubMed:19168442}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1Z57  (X-ray  1.70A  2VAG  (X-ray  1.80A  5J1V  (X-ray  2.52A  5J1W  (X-ray  2.42A  5X8I  (X-ray  1.90A  6FT8  (X-ray  1.45A  6FT9  (X-ray  1.87A  6FYO  (X-ray  2.32A  6G33  (X-ray  2.05A  6I5H  (X-ray  1.49A  6I5I  (X-ray  1.60A  6I5K  (X-ray  2.30A  6I5L  (X-ray  2.55A  6KHD  (X-ray  2.70A  6Q8K  (X-ray  2.29A  6Q8P  (X-ray  3.00A  6QTY  (X-ray  1.65A  6R3D  (X-ray  1.85A  6R6E  (X-ray  2.25A  6R6X  (X-ray  2.05A  6R8J  (X-ray  1.75A  6RAA  (X-ray  2.10A  6TW2  (X-ray  1.80A  6YTA  (X-ray  2.30A  6YTD  (X-ray  2.00A  6YTE  (X-ray  2.30A  6YTG  (X-ray  1.95A  6YTI  (X-ray  2.40A  6Z4Z  (X-ray  2.07A  6Z50  (X-ray  1.60A  6ZLN  (X-ray  1.70A  7AK3  (X-ray  2.50A  7O9Y  (X-ray  1.66A  7OA0  (X-ray  1.81A  7OPG  (X-ray  1.93A 
DBSNP rs55989135  rs6735666  rs56135616  rs35412475  rs35393352  rs12709 
Subcellular location [CC]Nucleus.
Mouse PG classificationNA
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