| Gene Information | |
|---|---|
| Gene Name | PRLR |
| Organism | Homo sapiens (Human) |
| Gene Length | 622 |
| Protein Names | Prolactin receptor (PRL-R) |
| Target Name | prolactin receptor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000113494 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P16471 |
| Gene Card | PRLR |
| Uniprot ID | P16471 |
| Pfam | PF09067 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999867923) |
| Ortholog in Animals | Alpaca_ PRLR ( ortholog_one2one ) Dog_ PRLR ( ortholog_one2one ) GuineaPig_ PRLR ( ortholog_one2one ) Macaque_ PRLR ( ortholog_one2one ) Mouse_ Prlr ( ortholog_one2one ) Pig_ PRLR ( ortholog_one2one ) Rat_ Prlr ( ortholog_one2one ) Rabbit_ PRLR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, LEPR |
| Tissue | adrenal.gland, ectocervix, endocervix, uterus |
| Tissue Specificity | Expressed in breast, placenta, kidney, liver and pancreas. {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.039539(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BP3 (X-ray 2.90A ) 2LFG (NMR - ) 2N7I (NMR - ) 3D48 (X-ray 2.50A ) 3MZG (X-ray 2.10A ) 3N06 (X-ray 2.00A ) 3N0P (X-ray 2.10A ) 3NCB (X-ray 2.10A ) 3NCC (X-ray 2.50A ) 3NCE (X-ray 2.00A ) 3NCF (X-ray 2.80A ) 4I18 (X-ray 3.24A ) |
| DBSNP | rs2228482 rs72478580 rs398122522 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.; [Isoform 7]: Secreted. |
| Mouse PG classification | NA |
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