| Gene Information | |
|---|---|
| Gene Name | MTPAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 582 |
| Protein Names | Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000107951 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NVV4 |
| Gene Card | MTPAP |
| Uniprot ID | Q9NVV4 |
| Pfam | PF03828; PF17797 |
| In ASD | no |
| Allosteric Prediction | no (-1.329662698) |
| Ortholog in Animals | Alpaca_ MTPAP ( ortholog_one2one ) Dog_ MTPAP ( ortholog_one2one ) GuineaPig_ MTPAP ( ortholog_one2one ) Macaque_ MTPAP ( ortholog_one2one ) Mouse_ Mtpap ( ortholog_one2one ) Pig_ MTPAP ( ortholog_one2one ) Rat_ Mtpap ( ortholog_one2one ) Rabbit_ MTPAP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TUT4, TENT2, TUT1, TUT7 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle. {ECO:0000269|PubMed:15547249}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3PQ1 (X-ray 3.10A ) |
| DBSNP | rs1047991 rs17855118 rs17857517 rs267606900 rs17855116 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18172165}. Mitochondrion {ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737}. |
| Mouse PG classification | NA |
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