| Gene Information | |
|---|---|
| Gene Name | POU2F2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 479 |
| Protein Names | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000028277 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P09086 |
| Gene Card | POU2F2 |
| Uniprot ID | P09086 |
| Pfam | PF00046; PF00157 |
| In ASD | no |
| Allosteric Prediction | no (-0.068975071) |
| Ortholog in Animals | Alpaca_ POU2F2 ( ortholog_one2one ) Dog_ POU2F2 ( ortholog_one2one ) GuineaPig_ POU2F2 ( ortholog_one2one ) Macaque_ POU2F2 ( ortholog_one2one ) Mouse_ Pou2f2 ( ortholog_one2one ) Pig_ POU2F2 ( ortholog_one2one ) Rat_ Pou2f2 ( ortholog_one2one ) Rabbit_ POU2F2 ( ortholog_one2one ) |
| Ohnologs | POU1F1, POU2F3, POU2F1, POU3F2, POU3F1, POU3F3 |
| Paralogs | POU1F1, POU2F3, POU4F3, POU3F3, POU6F1, POU4F1, CCDC160, HDX, POU5F1B, POU5F1, POU2F1, POU3F1, POU5F2, POU4F2, POU6F2, POU3F2, POU3F4 |
| Tissue | appendix, lymph.node, spleen, tonsil |
| Tissue Specificity | Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. {ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:3072196}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HDP (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus. |
| Mouse PG classification | NA |
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