| Gene Information | |
|---|---|
| Gene Name | CLIC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 236 |
| Protein Names | Chloride intracellular channel protein 3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000169583 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95833 |
| Gene Card | CLIC3 |
| Uniprot ID | O95833 |
| Pfam | PF13417 |
| In ASD | no |
| Allosteric Prediction | no (-1.047235114) |
| Ortholog in Animals | Alpaca_ CLIC3 ( ortholog_one2one ) Dog_ CLIC3 ( ortholog_one2one ) GuineaPig_ CLIC3 ( ortholog_one2one ) Macaque_ CLIC3 ( ortholog_one2one ) Mouse_ Clic3 ( ortholog_one2one ) Pig_ CLIC3 ( ortholog_one2one ) Rat_ Clic3 ( ortholog_one2one ) |
| Ohnologs | CLIC1 |
| Paralogs | CLIC2, GSTZ1, GSTO2, GDAP1L1, GSTT4, CLIC4, GSTT2, GSTT2B, CLIC1, EEF1G, GDAP1, GSTO1, CLIC6, CLIC5 |
| Tissue | lung, esophagus.mucosa, thyroid, vagina |
| Tissue Specificity | Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:17027078, ECO:0000269|PubMed:9880541}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FY7 (X-ray 1.95A ) 3KJY (X-ray 1.95A ) |
| DBSNP | rs2292923 |
| Subcellular location [CC] | Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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