| Gene Information | |
|---|---|
| Gene Name | CLIC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 253 |
| Protein Names | Chloride intracellular channel protein 4 (Intracellular chloride ion channel protein p64H1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000169504 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y696 |
| Gene Card | CLIC4 |
| Uniprot ID | Q9Y696 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | no (-0.525275053) |
| Ortholog in Animals | Alpaca_ CLIC4 ( ortholog_one2one ) Dog_ CLIC4 ( ortholog_one2one ) GuineaPig_ CLIC4 ( ortholog_one2one ) Macaque_ CLIC4 ( ortholog_one2one ) Mouse_ Clic4 ( ortholog_one2one ) Pig_ CLIC4 ( ortholog_one2one ) Rat_ Clic4 ( ortholog_one2many ) Rabbit_ CLIC4 ( ortholog_one2one ) |
| Ohnologs | CLIC5, CLIC6 |
| Paralogs | CLIC2, GSTZ1, GSTO2, GDAP1L1, CLIC3, GSTT4, GSTT2, GSTT2B, CLIC1, EEF1G, GDAP1, GSTO1, CLIC6, CLIC5 |
| Tissue | NA |
| Tissue Specificity | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346, ECO:0000269|PubMed:17636002}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002569(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2AHE (X-ray 1.80A ) 2D2Z (X-ray 2.20A ) 3OQS (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus matrix. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. |
| Mouse PG classification | NA |
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