Gene Information
Gene NamePTPN22
OrganismHomo sapiens (Human)
Gene Length807
Protein NamesTyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000134242 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y2R2
Gene CardPTPN22
Uniprot IDQ9Y2R2
PfamPF00102
In ASDyes
Allosteric Predictionyes (0.999775474)
Ortholog in AnimalsAlpaca_ PTPN22 ( ortholog_one2one )
Dog_ PTPN22 ( ortholog_one2one )
Macaque_ PTPN22 ( ortholog_one2one )
Mouse_ Ptpn22 ( ortholog_one2one )
Pig_ PTPN22 ( ortholog_one2one )
Rat_ Ptpn22 ( ortholog_one2one )
Rabbit_ PTPN22 ( ortholog_one2one )
OhnologsPTPN12
ParalogsPTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21
TissueNA
Tissue SpecificityExpressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. {ECO:0000269|PubMed:15208781}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2P6X  (X-ray  1.90A  )  2QCJ  (X-ray  3.00A  )  2QCT  (X-ray  2.80A  )  3BRH  (X-ray  2.20A  )  3H2X  (X-ray  2.20A  )  3OLR  (X-ray  2.50A  )  3OMH  (X-ray  2.90A  )  4J51  (X-ray  2.30A  )  7AAM  (X-ray  2.15A  ) 
DBSNP rs7416347  rs33996649  rs72650670  rs2476601 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:P29352}.
Mouse PG classificationNA
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