| Gene Information | |
|---|---|
| Gene Name | RNF144B |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000137393 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z419 |
| Gene Card | RNF144B |
| Uniprot ID | Q7Z419 |
| Pfam | PF01485 |
| In ASD | no |
| Allosteric Prediction | no (-0.79863883) |
| Ortholog in Animals | Alpaca_ RNF144B ( ortholog_one2one ) Dog_ RNF144B ( ortholog_one2one ) GuineaPig_ RNF144B ( ortholog_one2one ) Macaque_ RNF144B ( ortholog_one2one ) Mouse_ Rnf144b ( ortholog_one2one ) Pig_ RNF144B ( ortholog_one2one ) Rat_ Rnf144b ( ortholog_one2one ) Rabbit_ RNF144B ( ortholog_one2one ) |
| Ohnologs | RNF144A |
| Paralogs | RNF19A, RNF144A, RNF217, PRKN, RNF14, ARIH1, ANKIB1, ARIH2, RNF19B |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. {ECO:0000269|PubMed:16427630, ECO:0000269|PubMed:20300062}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation. |
| Mouse PG classification | NA |
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