| Gene Information | |
|---|---|
| Gene Name | CLDN8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 225 |
| Protein Names | Claudin-8 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000156284 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P56748 |
| Gene Card | CLDN8 |
| Uniprot ID | P56748 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-1.233051446) |
| Ortholog in Animals | Alpaca_ CLDN8 ( ortholog_one2one ) Dog_ CLDN8 ( ortholog_one2one ) GuineaPig_ CLDN8 ( ortholog_one2one ) Macaque_ CLDN8 ( ortholog_one2one ) Mouse_ Cldn8 ( ortholog_one2one ) Pig_ CLDN8 ( ortholog_one2one ) Rat_ Cldn8 ( ortholog_one2one ) Rabbit_ CLDN8 ( ortholog_one2one ) |
| Ohnologs | CLDN2, CLDN1, CLDN19 |
| Paralogs | CLDN1, CLDN5, CLDN3, CLDN20, CLDN11, CLDN14, CLDN18, CLDN7, CLDN10, CLDN9, CLDN17, CLDN24, CLDN22, CLDN23, CLDN4, CLDN15, CLDN19, CLDN34, CLDN2, CLDN25, CLDN16, CLDN6 |
| Tissue | colon, kidney, rectum, salivary.gland, thyroid, epididymis, submandibular.gland |
| Tissue Specificity | Expressed in the epididymis, mainly in the caput segment. {ECO:0000269|PubMed:17287494}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1557294 rs685967 rs686364 |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000269|PubMed:17287494}. Cell membrane {ECO:0000250|UniProtKB:Q9Z260}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells. {ECO:0000269|PubMed:17287494}. |
| Mouse PG classification | NA |
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