| Gene Information | |
|---|---|
| Gene Name | CLDN6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 220 |
| Protein Names | Claudin-6 (Skullin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000184697 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P56747 |
| Gene Card | CLDN6 |
| Uniprot ID | P56747 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-0.668388177) |
| Ortholog in Animals | Alpaca_ CLDN6 ( ortholog_one2one ) Dog_ CLDN6 ( ortholog_one2one ) GuineaPig_ CLDN6 ( ortholog_one2one ) Macaque_ CLDN6 ( ortholog_one2one ) Mouse_ Cldn6 ( ortholog_one2one ) Pig_ CLDN6 ( ortholog_one2one ) Rat_ Cldn6 ( ortholog_one2one ) Rabbit_ CLDN6 ( ortholog_one2one ) |
| Ohnologs | CLDN7, CLDN5, CLDN18, CLDN1, CLDN20 |
| Paralogs | CLDN1, CLDN5, CLDN8, CLDN3, CLDN20, CLDN11, CLDN14, CLDN18, CLDN7, CLDN10, CLDN9, CLDN17, CLDN24, CLDN22, CLDN23, CLDN4, CLDN15, CLDN19, CLDN34, CLDN2, CLDN25, CLDN16 |
| Tissue | NA |
| Tissue Specificity | Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. {ECO:0000269|PubMed:17804490}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2257295 |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z262}. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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