| Gene Information | |
|---|---|
| Gene Name | CLDN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 209 |
| Protein Names | Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000189143 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14493 |
| Gene Card | CLDN4 |
| Uniprot ID | O14493 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-0.835795044) |
| Ortholog in Animals | Dog_ CLDN4 ( ortholog_one2one ) GuineaPig_ CLDN4 ( ortholog_one2one ) Macaque_ CLDN4 ( ortholog_one2one ) Mouse_ Cldn13 ( ortholog_one2one ) Pig_ CLDN4 ( ortholog_one2one ) Rat_ Cldn4 ( ortholog_one2one ) Rabbit_ CLDN4 ( ortholog_one2one ) |
| Ohnologs | CLDN15, CLDN20 |
| Paralogs | CLDN1, CLDN5, CLDN8, CLDN3, CLDN20, CLDN11, CLDN14, CLDN18, CLDN7, CLDN10, CLDN9, CLDN17, CLDN24, CLDN22, CLDN23, CLDN15, CLDN19, CLDN34, CLDN2, CLDN25, CLDN16, CLDN6 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5B2G (X-ray 3.50A ) 7KP4 (X-ray 3.37A ) 7TDM (EM 6.90A ) 7TDN (EM 5.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000250|UniProtKB:O35054}. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. Note=CLDN4 is required for tight junction localization in the kidney. {ECO:0000250|UniProtKB:O35054}. |
| Mouse PG classification | NA |
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