| Gene Information | |
|---|---|
| Gene Name | STIM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 746 |
| Protein Names | Stromal interaction molecule 2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000109689 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9P246 |
| Gene Card | STIM2 |
| Uniprot ID | Q9P246 |
| Pfam | PF07647; PF16533 |
| In ASD | no |
| Allosteric Prediction | yes (0.18555397) |
| Ortholog in Animals | Alpaca_ STIM2 ( ortholog_one2one ) Dog_ STIM2 ( ortholog_one2one ) GuineaPig_ STIM2 ( ortholog_one2one ) Macaque_ STIM2 ( ortholog_one2one ) Mouse_ Stim2 ( ortholog_one2one ) Pig_ STIM2 ( ortholog_one2one ) Rat_ Stim2 ( ortholog_one2one ) Rabbit_ STIM2 ( ortholog_one2one ) |
| Ohnologs | STIM1 |
| Paralogs | STIM1 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues and tumor cell lines examined. {ECO:0000269|PubMed:11463338}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L5Y (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. |
| Mouse PG classification | NA |
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