| Gene Information | |
|---|---|
| Gene Name | PRRX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 253 |
| Protein Names | Paired mesoderm homeobox protein 2 (Paired-related homeobox protein 2) (PRX-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000167157 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99811 |
| Gene Card | PRRX2 |
| Uniprot ID | Q99811 |
| Pfam | PF00046; PF03826 |
| In ASD | no |
| Allosteric Prediction | no (-1.790437904) |
| Ortholog in Animals | Alpaca_ PRRX2 ( ortholog_one2one ) Dog_ PRRX2 ( ortholog_one2one ) GuineaPig_ PRRX2 ( ortholog_one2one ) Macaque_ PRRX2 ( ortholog_one2one ) Mouse_ Prrx2 ( ortholog_one2one ) Pig_ PRRX2 ( ortholog_one2one ) Rat_ Prrx2 ( ortholog_one2one ) Rabbit_ PRRX2 ( ortholog_one2one ) |
| Ohnologs | PRRX1 |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | prostate, skin, testis, cervix, dura.mater, mitral.valve, penis, smooth.muscle, tricuspid.valve |
| Tissue Specificity | In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis. {ECO:0000269|PubMed:9665387}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}. |
| Mouse PG classification | NA |
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