| Gene Information | |
|---|---|
| Gene Name | RHOB |
| Organism | Homo sapiens (Human) |
| Gene Length | 196 |
| Protein Names | Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6) |
| Target Name | rho-related gtp-binding protein rhob |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000143878 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P62745 |
| Gene Card | RHOB |
| Uniprot ID | P62745 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | yes (0.534197734) |
| Ortholog in Animals | Alpaca_ RHOB ( ortholog_one2one ) Dog_ RHOB ( ortholog_one2one ) Mouse_ Rhob ( ortholog_one2one ) Pig_ RHOB ( ortholog_one2one ) Rabbit_ RHOB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RHOC, RHOA, RND1, CDC42, RHOT1, RHOBTB3, RHOT2, RAC1, RAC3, RHOJ, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2FV8 (X-ray 1.90A ) 6HXU (X-ray 1.19A ) 6SGE (X-ray 1.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. |
| Mouse PG classification | NA |
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