| Gene Information | |
|---|---|
| Gene Name | DNASE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 282 |
| Protein Names | Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000213918 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P24855 |
| Gene Card | DNASE1 |
| Uniprot ID | P24855 |
| Pfam | PF03372 |
| In ASD | no |
| Allosteric Prediction | no (-0.407785963) |
| Ortholog in Animals | Alpaca_ DNASE1 ( ortholog_one2one ) Dog_ DNASE1 ( ortholog_one2one ) Macaque_ DNASE1 ( ortholog_one2one ) Mouse_ Dnase1 ( ortholog_one2one ) Pig_ DNASE1 ( ortholog_one2one ) Rat_ Dnase1 ( ortholog_one2one ) Rabbit_ DNASE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DNASE1L2, DNASE1L1, DNASE1L3 |
| Tissue | small.intestine |
| Tissue Specificity | Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4AWN (X-ray 1.95A ) |
| DBSNP | rs8176927 rs77254040 rs8176928 rs530214101 rs8176919 rs1799891 rs148373909 rs8176940 rs1053874 rs8176939 rs8176924 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:2277032}. Zymogen granule {ECO:0000305}. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. |
| Mouse PG classification | HPG |
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