| Gene Information | |
|---|---|
| Gene Name | CD302 |
| Organism | Homo sapiens (Human) |
| Gene Length | 232 |
| Protein Names | CD302 antigen (C-type lectin BIMLEC) (C-type lectin domain family 13 member A) (DEC205-associated C-type lectin 1) (Type I transmembrane C-type lectin receptor DCL-1) (CD antigen CD302) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000241399 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IX05 |
| Gene Card | CD302 |
| Uniprot ID | Q8IX05 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-1.561045744) |
| Ortholog in Animals | Alpaca_ CD302 ( ortholog_one2one ) Dog_ CD302 ( ortholog_one2one ) GuineaPig_ CD302 ( ortholog_one2one ) Mouse_ Cd302 ( ortholog_one2one ) Pig_ CD302 ( ortholog_one2one ) Rat_ Cd302 ( ortholog_one2one ) Rabbit_ CD302 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LY75, MRC1, PLA2R1, MRC2 |
| Tissue | NA |
| Tissue Specificity | Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. {ECO:0000269|PubMed:12824192, ECO:0000269|PubMed:17947679}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NAN (NMR - ) |
| DBSNP | rs34068933 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, filopodium {ECO:0000269|PubMed:17947679}. Cytoplasm, cell cortex {ECO:0000269|PubMed:17947679}. Cell projection, microvillus {ECO:0000269|PubMed:17947679}. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface. |
| Mouse PG classification | NA |
| click here to return to the previous page | |