| Gene Information | |
|---|---|
| Gene Name | CLCN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 818 |
| Protein Names | H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000109572 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P51790 |
| Gene Card | CLCN3 |
| Uniprot ID | P51790 |
| Pfam | PF00571; PF00654 |
| In ASD | no |
| Allosteric Prediction | yes (0.53812992) |
| Ortholog in Animals | Alpaca_ CLCN3 ( ortholog_one2one ) Dog_ CLCN3 ( ortholog_one2one ) GuineaPig_ CLCN3 ( ortholog_one2one ) Macaque_ CLCN3 ( ortholog_one2one ) Mouse_ Clcn3 ( ortholog_one2one ) Pig_ CLCN3 ( ortholog_one2one ) Rat_ Clcn3 ( ortholog_one2one ) Rabbit_ CLCN3 ( ortholog_one2one ) |
| Ohnologs | CLCN4, CLCN5 |
| Paralogs | CLCN6, CLCNKB, CLCNKA, CLCN1, CLCN7, CLCN4, CLCN2, CLCN5 |
| Tissue | NA |
| Tissue Specificity | Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). {ECO:0000269|PubMed:10198195, ECO:0000269|PubMed:11967229, ECO:0000269|PubMed:12471024}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1190062987 rs1732900321 |
| Subcellular location [CC] | [Isoform 1]: Early endosome membrane {ECO:0000269|PubMed:12471024}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:12471024}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P51791}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P51792}; Multi-pass membrane protein {ECO:0000255}. Note=Isoform 1 is localized mainly in late endosomes. {ECO:0000269|PubMed:12471024}.; [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:12471024}; Multi-pass membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11967229}; Multi-pass membrane protein {ECO:0000269|PubMed:11967229}. Note=Isoform 2 is mainly enriched in the Golgi (PubMed:12471024). Colocalizes with SLC9A3R1/EBP50 in membrane ruffles (PubMed:11967229). {ECO:0000269|PubMed:11967229, ECO:0000269|PubMed:12471024}. |
| Mouse PG classification | NA |
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